Symptoms and Quality of Life in Patients With Heterotopic Gastric Mucosa (HGM)

Sponsor
Knappschaft Kliniken GmbH
Study ID
NCT07510984
Status
Recruiting
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Conditions

  • Dyspepsia
  • Dysphagia
  • Gastric Inlet Patches
  • Heterotopic Gastric Mucosa of the Proximal Esophagus

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to learn whether heterotopic gastric mucosa (HGM) in the upper esophagus is associated with swallowing difficulties (dysphagia) in adults undergoing a medically indicated gastroscopy. The main questions it aims to answer are: * Is the presence of HGM associated with dysphagia? * Is the presence of HGM associated with dyspepsia and reduced health-related quality of life? Among participants reporting dysphagia, what is the distribution of oropharyngeal versus esophageal dysphagia, and is this related to the presence of HGM? If there is a comparison group: Researchers will compare participants with endoscopically confirmed HGM to participants without HGM to determine whether dysphagia, dyspepsia symptoms, and quality-of-life measures differ between groups. Participants will: Complete pseudonymised questionnaires about dysphagia, dyspepsia symptoms, and quality of life before the gastroscopy. Undergo the medically indicated gastroscopy as planned; the endoscopist will assess whether HGM is present based on the endoscopic appearance, and routine endoscopy findings will be documented.

Key Dates

First listed
Apr 6, 2026
Start date
Mar 24, 2026
Status verified
Apr 2026
Primary completion
Mar 24, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
721 participants (estimated)

Arms

  • Arm: HGM present
    Participants with endoscopic evidence of heterotrophic gastric mucosa
  • Arm: No HGM
    Participants without endoscopic evidence of heterotrophic gastric mucosa

Primary Outcome Measure

Dysphagia Symptom Burdon (EAT-10 und SSQ) [ Time Frame: Baseline (prior to gastroscopy; single assessment at enrollment) ]

Central Contacts

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