Digital MEDIcal TWIN for the Prediction of Arrhythmic Sudden Cardiac Death After a Myocardial Infarction

Sponsor
University Hospital, Bordeaux
Study ID
NCT07527494
Status
Not Yet Recruiting

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Conditions

  • Myocardial Infarction
  • Sudden Cardiac Death

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Programmed ventricular stimulation — PROCEDURE
    Invasive cardiac electrophysiology (EP) study
  • Cardiac CT scan — PROCEDURE
    Cardiac CT scan with contrast enhancement

Study Details

TWIN-SCD STEMI is a multicentric prospective, non-randomized pilot study designed to establish a multiparametric model for predicting life-threatening ventricular arrhythmias in patients experiencing their first myocardial infarction. The primary objective of the study is to develop an algorithm with superior predictive performance (sensitivity and specificity) compared to the currently used criterion for the implantation of a cardiac defibrillator, which is a left ventricular ejection fraction (LVEF) of less than 35%.

Key Dates

First listed
Apr 14, 2026
Start date
Apr 15, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2033
Completion
Dec 31, 2034

Study Design

Enrollment
1,000 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: Single arm
    Programmed ventricular stimulation and CT scan

Primary Outcome Measure

Occurrence of sudden cardiac death or sustained ventricular arrhythmia [ Time Frame: From enrollment to the end of the 60-months follow-up ]

Central Contacts

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