High-Flow Nasal Cannula After Major Abdominal Surgery to Prevent Postoperative Pulmonary Complications

Sponsor
Uijeongbu St. Mary Hospital
Study ID
NCT07528404
Status
Not Yet Recruiting

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Conditions

  • Atelectasis
  • Pneumonia
  • Postoperative Complications
  • Respiratory Insufficiency

Eligibility Criteria

Sex
ALL
Age
19 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • High flow nasal cannula (HFNC) — DEVICE
    High-flow nasal cannula (HFNC) will be applied prophylactically immediately after extubation following major abdominal surgery. Heated and humidified oxygen will be delivered through a high-flow nasal cannula system and maintained for 24 hours postoperatively according to the study protocol.
  • Standard oxygen therapy — OTHER
    Standard postoperative oxygen therapy will be administered immediately after extubation following major abdominal surgery according to usual institutional practice and the study protocol, without prophylactic high-flow nasal cannula.

Study Details

Major abdominal surgery is associated with a substantial risk of early postoperative pulmonary complications, including atelectasis, hypoxemia, pneumonia, and increased need for respiratory support. High-flow nasal cannula (HFNC) provides warmed and humidified oxygen at high flow rates and may improve oxygenation, reduce respiratory workload, and support lung volume during the immediate postoperative period. However, whether routine prophylactic HFNC after major abdominal surgery reduces clinically significant postoperative pulmonary complications remains uncertain. This prospective, single-center, randomized controlled trial will evaluate whether prophylactic HFNC applied for 24 hours immediately after extubation reduces postoperative pulmonary complications compared with standard postoperative respiratory care in adult patients undergoing major abdominal surgery under general anesthesia with an actual anesthetic duration of 3 hours or longer.

Key Dates

First listed
Apr 14, 2026
Start date
Jul 1, 2026
Status verified
Apr 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
580 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: HFNC group
    Participants randomized to this arm will receive prophylactic high-flow nasal cannula (HFNC) immediately after extubation following major abdominal surgery. HFNC will be initiated in the post-anesthesia care unit or intensive care unit and maintained for 24 hours postoperatively according to the study protocol.
  • Active Comparator: Standard oxygen group
    Participants randomized to this arm will receive standard postoperative oxygen therapy immediately after extubation following major abdominal surgery. Oxygen will be administered according to usual institutional practice and the study protocol, without prophylactic high-flow nasal cannula.

Primary Outcome Measure

Postoperative pulmonary complications (PPCs) [ Time Frame: Within 7 days after surgery ]

Central Contacts

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