Study on Eye-Brain Cross-Organ Mapping and Systemic Disease Association Based on Multimodal Big Data

Sponsor
Beijing Friendship Hospital
Study ID
NCT07541651
Status
Not Yet Recruiting

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Conditions

  • Cataract
  • Cerebral Small Vessel Disease
  • Cerebrovascular Stenosis
  • Diabetic Eye Diseases
  • Vitreous Hemorrhage

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Interventions

  • No interventions were involved in this study. — OTHER
    No interventions were involved in this study.

Study Details

This project integrates multimodal eye data (CFP, OCT, OCTA) from 50,000 cases, brain MR data from 150,000 cases, and ICD diagnoses, medical orders, and test results from an eye-brain paired cohort of 8,000 cases to construct an eye-brain cross-modal mapping model and an eye-brain-systemic disease association model. It aims to clarify the quantitative associations between multimodal ocular features and brain structural and vascular characteristics as well as systemic disease ICD diagnoses, thereby uncovering the cross-organ and cross-modal linkage mechanisms between the eye and brain. Ultimately, it seeks to achieve mapping and prediction of brain imaging features based on ocular data, enable ocular-based diagnosis and prediction of various diseases, and contribute significantly to early disease screening, risk stratification, and optimization of clinical diagnosis and treatment.

Key Dates

First listed
Apr 21, 2026
Start date
Apr 25, 2026
Status verified
Feb 2026
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
208,000 participants (estimated)

Arms

  • Arm: Ophthalmic Data Cohort
  • Arm: Cerebral Data Cohort
  • Arm: Oculo-Cerebral Matched Cohort
  • Arm: Clinical Correlation Cohort

Primary Outcome Measure

Performance of Systemic Disease Prediction Models [ Time Frame: From the time of model construction and consistency alignment during the study period to the end of the 12-month follow-up after study initiation. ]

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