A Prospective Observational Cohort Study Protocol for Disease Severity Stratification and Prognosis Assessment in Patients With Pneumonia

Sponsor
Zhonghao Fang
Study ID
NCT07567911
Status
Not Yet Recruiting

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Conditions

  • Pneumonia
  • Severe Pneumonia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

This is a prospective, multicenter observational cohort study involving approximately 2,700 patients, designed to delineate the natural history of pneumonia by tracking the complete clinical course and dynamic multi-omics evolution from the acute phase to recovery; the study aims to quantify severe conversion rates and mortality by comparing baseline characteristics, pathogen distribution, and immune response trajectories between severe and non-severe groups, ultimately revealing the underlying molecular mechanisms of disease progression and optimizing clinical risk stratification strategies.

Key Dates

First listed
May 5, 2026
Start date
May 1, 2026
Status verified
Apr 2026
Primary completion
May 1, 2026
Completion
May 28, 2028

Study Design

Enrollment
2,700 participants (estimated)

Arms

  • Arm: pneumonia
  • Arm: Severe pneumonia
  • Arm: Non-infection control group

Primary Outcome Measure

28-day all-cause mortality [ Time Frame: 28-day period following enrollment ]

Central Contacts

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