Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger

Sponsor
Bedaya Hospital
Study ID
NCT07569289
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Infertility

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 40 Years
Healthy Volunteers
Not accepted

Interventions

  • Double trigger — DRUG
    Triptorelin (0.2 mg/S.C ) and HCG (10000 IU/I.M) are administered 38 to 39 h and 35 to 36 h prior to ovum pick-up., respectively.
  • HCG trigger — DRUG
    HCG (10000 IU/I.M) is administered 35 to 36 h prior to ovum pick-up.

Study Details

The aim of this randomized controlled study is to compare the efficacy of double trigger protocol \[ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively \] with HCG in triggering ovulation in patients with expected poor response to ovarian stimulation

Key Dates

First listed
May 6, 2026
Start date
Jun 1, 2026
Status verified
Apr 2026
Primary completion
Dec 1, 2027
Completion
Apr 1, 2028

Study Design

Enrollment
164 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Double trigger
    GnRH agonist is administered 38 - 39 hours prior to ovum pick-up and HCG is administered 35 - 36 hours prior to ovum pick-up, respectively.
  • Active Comparator: HCG trigger
    HCG is administered 35 - 36 h prior to ovum pick-up

Primary Outcome Measure

Metaphase-II oocytes rate [ Time Frame: Ten to fifteen days after starting ovarian stimulation ]

Central Contacts

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