Successive Doses of GnRH Agonist Versus Single Dose of GnRH Agonist to Trigger Ovulation in Hyper-responders

Sponsor
Bedaya Hospital
Study ID
NCT07569315
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Infertility

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 40 Years
Healthy Volunteers
Not accepted

Interventions

  • Successive doses GnRH agonist — DRUG
    GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup. Two additional doses of triptorelin ( 0.1 mg / S.C ) are administered subcutaneously 12 and 24 hours after the first dose of GnRH agonist.
  • Single dose GnRH agonist — DRUG
    GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) is administered 36 hours before ovum pickup.

Study Details

The aim of this randomized controlled study is to compare the efficacy of three successive doses of a GnRH agonist ( administered 36 , 24 and 12 hours before oocyte retrieval ) with a single dose of a GnRH agonist ( administered 36 hours before oocyte retrieval ) in triggering ovulation in hyper-responders

Key Dates

First listed
May 6, 2026
Start date
Jun 1, 2026
Status verified
May 2026
Primary completion
Dec 1, 2027
Completion
Apr 1, 2028

Study Design

Enrollment
190 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Successive doses GnRH agonist
    Three successive doses of GnRH agonist are administered 36 , 24 and 12 hours before oocyte retrieval
  • Active Comparator: Single dose GnRH agonist
    A single dose of GnRH agonist is administered 36 hours before oocyte retrieval

Primary Outcome Measure

Metaphase-II oocytes rate [ Time Frame: Ten to fifteen days after starting ovarian stimulation ]

Central Contacts

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