Improving Patient Assessment After Acute Kidney Injury (AKI)

Sponsor
University of Nottingham
Study ID
NCT07569588
Status
Recruiting
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Conditions

  • Acute Kidney Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Iohexol renal clearance measurement — DIAGNOSTIC_TEST
    Gold standard measurement of glomerular filtration rate.
  • Cystatin C — DIAGNOSTIC_TEST
    Estimated GFR using serum cystatin C
  • Creatinine — DIAGNOSTIC_TEST
    eGFR from serum creatinine level
  • Semi structured interview — OTHER
    Semi structured interview to explore patient experiences. Purposive sampling will be used to explore a wide range of perspectives and transcripts will be analysed using thematic analysis to develop codes and themes.
  • Participatory workshop — OTHER
    Group workshop using qualitative methods. Purposive sampling will be used to explore a wide range of perspectives and transcripts will be analysed using thematic analysis to develop codes and themes. These will be used to develop consensus recommendations.
  • Metagenome analysis — DIAGNOSTIC_TEST
    Analysis of the metagenome using faecal samples of participants after acute kidney injury
  • Bioimpedance analysis — DIAGNOSTIC_TEST
    Estimation of body composition
  • Patient reported outcome measures — OTHER
    EQ-5D-5L, KSQ, WHO-DAS 2.0, K10
  • Measurement of physical performance — OTHER
    Hand grip, Short physical performance battery

Study Details

The goal of this clinical trial is to improve patient care after acute kidney injury (AKI). It has three related parts. The main questions it aims to answer are: 1. Is creatinine or cystatin a more reliable assessment of kidney function after AKI? 2. What are the experiences of patients after AKI? 3. What interventions should be recommended to improve assessment and support of patients after AKI? Participants will be asked to do one or more of: * blood tests to measure kidney function in different ways * have measurement of their body composition * complete questionnaires about their symptoms * have an interview with a researcher about their experiences * discussion to develop an action plan based on findings

Key Dates

First listed
May 6, 2026
Start date
Feb 16, 2026
Status verified
Dec 2025
Primary completion
Jan 31, 2028
Completion
Oct 31, 2029

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Observational study
    Patients 3 months after hospitalised acute kidney injury
  • Arm: Qualitative study
    Patients 3 months after hospitalised acute kidney injury
  • Arm: Participatory workshops
    Individuals with personal or professional experience of acute kidney injury

Primary Outcome Measure

The proportion of eligible patients who agree to participate [ Time Frame: 3 months ]

Central Contacts

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