AIC Genotyping Study

Sponsor
Barts & The London NHS Trust
Study ID
NCT07574697
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

To quantify genetic variants in a focused DCM gene panel among AF-induced cardiomyopathy (AIC) and positive/negative controls

Key Dates

First listed
May 8, 2026
Start date
Mar 25, 2026
Status verified
May 2026
Primary completion
Mar 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
299 participants (estimated)

Arms

  • Arm: AF induced Cardiomyopathy (Cases)
    Patients with LVSD during rate-controlled, persistent AF who improve their LVEF after sustained SR is achieved using catheter ablation or cardioversion.
  • Arm: AF-preserved EF (Negative controls)
    Patients without LVSD during rate-controlled, persistent AF
  • Arm: AF/HF non-responders (Positive controls)
    Patients with LVSD during rate-controlled, persistent AF who do not significantly improve their LVEF after sustained SR is achieved using catheter ablation or cardioversion.

Primary Outcome Measure

DCM gene prevalence relative to negative control [ Time Frame: On day of baseline testing (1 day) ]

Central Contacts

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