Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

Part of paid clinical trials in Pelham, Alabama.

Sponsor
Amgen
Study ID
NCT07575399
Phase
PHASE3
Status
Recruiting
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Conditions

  • Obesity or Overweight

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • Maridebart Cafraglutide — DRUG
    Maridebart cafraglutide will be administered via subcutaneous (SC) injection.

Study Details

Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overweight.

Key Dates

Start date
May 11, 2026
Status verified
Jun 2026
Primary completion
Jan 3, 2028
Completion
Feb 28, 2028

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: MariTide Arm 1
    Participants will receive maridebart cafraglutide dosing schedule 1 during the treatment period.
  • Experimental: MariTide Arm 2
    Participants will receive maridebart cafraglutide dosing schedule 2 during the treatment period.

Primary Outcome Measure

Percent Change from Baseline in Body Weight at Week 68 [ Time Frame: Week 68 ]

Central Contacts

Locations (39)

FacilityCityStateZIPSite coordinators
Cahaba Research, Inc.PelhamAlabama35124-
Arizona Clinical TrialsChandlerArizona85224-
Epic Medical Research - Sun CitySun CityArizona85351-
Desert Oasis Healthcare Medical GroupPalm SpringsCalifornia92262-
Inland Empire Liver FoundationRialtoCalifornia92377-
Peninsula Research AssociatesRolling Hills EstatesCalifornia90274-
Apex Clinical ResearchSan DiegoCalifornia92120-
Southern California Clinical ResearchSanta AnaCalifornia92701-
Aga Clinical TrialsHialeahFlorida33012-
South Florida Clinical ResearchMargateFlorida33063-
New Horizon Research CenterMiamiFlorida33165-
Research Institute of South FloridaMiamiFlorida33173-
Clinical Neuroscience SolutionsOrlandoFlorida32801-
Florida Institute for Clinical ResearchOrlandoFlorida32825-
Progressive Medical ResearchPort OrangeFlorida32127-
Charter Research - The VillagesThe VillagesFlorida32162-
Nsc ResearchJohns CreekGeorgia30024-
Rophe Adult and Pediatric Medicine/Sky Clinical Research Network GroupUnion CityGeorgia30291-
North Georgia Clinical ResearchWoodstockGeorgia30189-
Solaris Clinical ResearchMeridianIdaho83646-
Endeavor HealthSkokieIllinois60077-
Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research DivisionTroyMichigan48098-
Sky Integrative Medical CenterRidgelandMississippi39157-
Excel Clinical ResearchLas VegasNevada89109-
Rochester Clinical ResearchRochesterNew York14609-
Centricity Research Morehead City SpecialtyMorehead CityNorth Carolina28557-
Accellacare of RaleighRaleighNorth Carolina27609-
Accellacare Research of WilmingtonWilmingtonNorth Carolina28401-
Lynn Health Science InstituteOklahoma CityOklahoma73112-
Altoona Center for Clinical ResearchDuncansvillePennsylvania16635-
Epic Medical Research - DeSotoDeSotoTexas75115-
South Texas Research InstituteEdinburgTexas78539-
Biopharma Informatic, LLCHoustonTexas77043-
Research Physicians Network, LLCHoustonTexas77089-
Texas Institute of CardiologyMcKinneyTexas75071-
North Hills Medical ResearchNorth Richland HillsTexas76180-
VIP TrialsSan AntonioTexas78230-
Northwest Houston Heart CenterTomballTexas77375-
Eastside Research Associates Health ResearchRedmondWashington98052-

Find similar trials in Pelham, AL

By research site
Cahaba Research, Inc.· Pelham, ALArizona Clinical Trials· Chandler, AZEpic Medical Research - Sun City· Sun City, AZDesert Oasis Healthcare Medical Group· Palm Springs, CAInland Empire Liver Foundation· Rialto, CAPeninsula Research Associates· Rolling Hills Estates, CA

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