Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS

Sponsor
Institute of Hematology & Blood Diseases Hospital, China
Study ID
NCT07578675
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Study Details

Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment. Such deficits-including declines in memory, learning, processing speed, and executive function-reduce daily living abilities and increase risks of falls and depression. Functional near-infrared spectroscopy (fNIRS) enables real-time monitoring of oxygenated and deoxygenated hemoglobin fluctuations, reflecting brain network function. This study aims to identify affected neural network regions in anemic patients and visualize connectivity changes using heatmaps and arc-based mapping. The findings will support early detection of cognitive impairment and guide precise clinical interventions, ultimately informing individualized treatment strategies to enhance therapeutic outcomes and quality of life.

Key Dates

First listed
May 11, 2026
Start date
Oct 11, 2025
Status verified
May 2026
Primary completion
Mar 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
323 participants (estimated)

Primary Outcome Measure

Concentration changes in oxygenated hemoglobin (HbO) and de-oxygenated hemoglobin (HbR) [ Time Frame: Patients will be assessed within 48 hours of admission. ]

Central Contacts

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