Effect of LSD on Lipid Profiles in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)

Sponsor
Northern Jiangsu People's Hospital
Study ID
NCT07588334
Status
Not Yet Recruiting

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Conditions

  • Cirrhosis, Liver
  • Lipid Profiles
  • Portal Hypertension
  • Splenectomy; Status

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Study Details

Patients with liver cirrhosis frequently exhibit dyslipidemia due to impaired hepatic lipid synthesis, altered bile acid metabolism, and portal hypertension. Laparoscopic Splenectomy and Azygoportal Disconnection (LSD) is commonly used to treat Cirrhosis with Portal Hypertension Bleeding in these patients, but its impact on lipid profiles over 2 years remains poorly characterized. This study will follow patients undergoing LSD to measure changes in serum lipid parameters before and after surgery, identify risk factors for lipid profile deterioration or improvement, and determine whether LSD can ameliorate dyslipidemia in the long term, thereby informing metabolic management strategies in cirrhotic patients.

Key Dates

First listed
May 14, 2026
Start date
May 1, 2026
Status verified
May 2026
Primary completion
Feb 28, 2029
Completion
Feb 28, 2029

Study Design

Enrollment
30 participants (estimated)

Primary Outcome Measure

Total cholesterol (TC) level [ Time Frame: at preoperative baseline, postoperative month 1, month 3, month 6, month 12, month 18, month 24 ]

Central Contacts

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