Postoperative Hypofractionated Whole Pelvic Radiotherapy in Cervical and Endometrial Cancer

Sponsor
Siriraj Hospital
Study ID
NCT07595224
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Hypofractionated Radiotherapy — RADIATION
    Postoperative hypofractionated whole pelvic radiotherapy delivered with a higher dose per fraction and a reduced number of treatment sessions compared to conventional radiotherapy, while maintaining a similar total radiation dose.
  • Conventional Radiotherapy — RADIATION
    Standard postoperative whole pelvic radiotherapy delivered using conventional fractionation with a lower dose per fraction over a greater number of treatment sessions.

Study Details

This study aims to evaluate a shorter course of postoperative pelvic radiotherapy in patients with cervical and endometrial cancer. The standard radiotherapy schedule usually requires many treatment sessions over several weeks, which can be burdensome for patients and may affect their ability to complete treatment. This study will compare a shorter radiotherapy schedule (hypofractionated radiotherapy) with the standard schedule. Both treatments deliver a similar total radiation dose, but the shorter schedule reduces the number of hospital visits and overall treatment time. Participants will be randomly assigned to receive either the shorter or standard radiotherapy after surgery. The study will evaluate side effects, treatment effectiveness, and quality of life. The goal is to determine whether the shorter treatment is as safe and effective as the standard approach.

Key Dates

First listed
May 19, 2026
Start date
Mar 11, 2026
Status verified
May 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2028

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: CVRT
    Participants receive standard postoperative whole pelvic radiotherapy.
  • Experimental: HYPO
    Participants receive postoperative hypofractionated whole pelvic radiotherapy.

Primary Outcome Measure

Incidence of Acute Treatment-Related Toxicity [ Time Frame: During treatment and up to 3 months after completion of radiotherapy ]

Central Contacts

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