Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery

Sponsor
Sixth Affiliated Hospital, Sun Yat-sen University
Study ID
NCT07601256
Status
Not Yet Recruiting

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Conditions

  • Lung Injury
  • Sepsis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Inhalation Anesthesia — DRUG
    The inhalation group will be maintained with inhaled sevoflurane and a continuous intravenous infusion of remifentanil.
  • intravenous anesthesia — DRUG
    The intravenous group will be maintained with continuous intravenous infusions of both ciprofol and remifentanil.

Study Details

This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery. The primary goal is to determine if the choice of anesthetic technique influences the incidence or severity of this complication. Participants will be randomly assigned to one of the two anesthetic regimens during surgery. They will receive daily in-hospital assessments for lung injury and other outcomes and will be followed for clinical outcomes until 90 days after the procedure.

Key Dates

First listed
May 22, 2026
Start date
Aug 15, 2026
Status verified
Dec 2025
Primary completion
Dec 30, 2030
Completion
Dec 30, 2030

Study Design

Enrollment
480 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: inhalation group
  • Experimental: intravenous group

Primary Outcome Measure

Ventilator-free days at 7 days after surgery [ Time Frame: From the surgery to the 7th day ]

Central Contacts

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