RAD ONC FREEDOM Oncology Pain

Conditions

• Cancer Pain

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Radiosurgery — RADIATION
  intracranial functional stereotactic radiosurgery (FnSRS) to the triple target: centromedian-parafasciular complex bilaterally, and the hypophysis

Study Details

The investigators propose to conduct a study in medically refractory cancer pain patients utilizing radiosurgery to ablate the pituitary hypophysis, as well as neuromodulate the centromedian and parafascicular complexes within the thalami - the so-called triple target. This involves treating the pituitary hypophysis and thalamus to a dose of 90 Gy. These patients will have previously failed to achieve adequate pain control with opioid pain regimens and interventional approaches. The trial will involve a multidisciplinary approach involving radiation oncology, neurosurgery, palliative care, and medical oncology colleagues across UCLA.

Key Dates

First listed

May 26, 2026

Start date

Jun 9, 2026

Status verified

Jun 2026

Primary completion

Jun 1, 2028

Completion

Jun 1, 2029

Study Design

Enrollment

19 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Arms

• Experimental: Treatment
  intracranial functional stereotactic radiosurgery (FnSRS) to the centromedian-parafasciular complex bilaterally, and the hypophysis.

Primary Outcome Measure

Pain Inventory [ Time Frame: - Baseline: Daily measurements on three separate days prior to treatment (Day -7 +/- 3 days, Day -3 +/- 1 day, Day -2 +/- 1 day)- Post-baseline: Days +1, 2, 3, 4, 7, 14, 21, 28 ]

Central Contacts

• William Delery
  310-825-5111
  [email protected]
• Christy Palodichuk
  +1 310-794-2971
  [email protected]

Locations (1)

Find similar trials in Los Angeles, CA

Related Studies

• Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
  Recruiting · Cedars-Sinai Medical Center · Los Angeles, California
• Cancer Pain Management Using a Web-based Intervention
  Recruiting · University of Texas at Austin · Austin, Texas
• Virtual Reality Therapy for Cancer-Treatment Associated Symptoms
  Recruiting · University of Maryland, Baltimore · Baltimore, Maryland
• Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
  PHASE1 · Not Yet Recruiting · Nyree Penn · Aventura, Florida