Muscle Ultrasound for Sarcopenia Assessment in Kidney Transplant Recipients

Sponsor
Sichuan Provincial People's Hospital
Study ID
NCT07607236
Status
Not Yet Recruiting

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Conditions

  • Kidney Transplantation
  • Muscle Wasting
  • Sarcopenia

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Muscle Ultrasound — DIAGNOSTIC_TEST
    Multimodal muscle ultrasound assessment performed for evaluation of sarcopenia in kidney transplant recipients.

Study Details

This is a single-center prospective observational study designed to evaluate the effectiveness of multimodal muscle ultrasound for the assessment of sarcopenia in kidney transplant recipients. Adult patients undergoing kidney transplantation will undergo both muscle ultrasound and bioelectrical impedance analysis (BIA) at predefined time points before and after transplantation. The primary objective is to evaluate the diagnostic performance of muscle ultrasound for sarcopenia assessment, including its correlation and agreement with BIA-derived skeletal muscle index (BIA-SMI), as well as its diagnostic accuracy. Secondary objectives include describing the longitudinal changes in sarcopenia prevalence and muscle-related parameters from the pre-transplant period to 1 year after transplantation. The study aims to provide evidence for a convenient, noninvasive, radiation-free, and reliable method for sarcopenia assessment in kidney transplant recipients.

Key Dates

First listed
May 26, 2026
Start date
May 30, 2026
Status verified
May 2026
Primary completion
Aug 30, 2027
Completion
Jan 30, 2028

Study Design

Enrollment
140 participants (estimated)

Arms

  • Arm: Kidney Transplant Recipients
    Adult kidney transplant recipients undergoing prospective assessment of sarcopenia using multimodal muscle ultrasound and bioelectrical impedance analysis (BIA).

Primary Outcome Measure

Area under the receiver operating characteristic (ROC) curve of muscle ultrasound for detecting sarcopenia using BIA-derived skeletal muscle index (BIA-SMI) as the reference standard. [ Time Frame: From baseline to 1 year after kidney transplantation ]

Central Contacts

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