Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR)

Sponsor
Boston University
Study ID
NCT07607743
Status
Not Yet Recruiting

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Conditions

  • Opioid Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Behavioral Activation (BA) — BEHAVIORAL
    Trained study interventionists will deliver the manualized BA intervention aimed at increasing meaningful and enjoyable non-substance-related activities in early recovery. This intervention will include 12 individual sessions delivered to participants every other week for 6 months. The BA intervention will be delivered remotely by telephone or video visit to minimize treatment burden on patients.
  • Attendance Reinforcement (AR) — BEHAVIORAL
    A voucher incentive protocol will be implemented with increasing rewards based on clinical attendance at outpatient addiction treatment visits. The timing of clinical visits will be determined by site-specific usual care practices at both sites. Participants are expected to earn a range of payments for visit attendance according to their unique clinical schedule (which is dictated by their addiction medicine clinical team, not by research investigators).
  • Peer-Delivered Motivational Interviewing (PDMI) — BEHAVIORAL
    Trained study peer recovery coaches will deliver a multi-session intervention aimed at increasing treatment confidence for treatment continuation and providing social support during early recovery. The peer recovery coach will deliver brief MI (20-minute) individual sessions remotely every other week over the 6-month period (total 12 sessions). Peer interventionists will also be informed about local recovery resources to provide navigation support individually. PDMI will be delivered remotely by telephone or video visit.

Study Details

Buprenorphine, a medication for opioid use disorder (MOUD), is associated with decreased opioid overdose and all-cause mortality. Treatment outcomes improve if patients remain on MOUD for at least six months, a period recommended by expert guidelines, although most studies report retention on MOUD of 50-65% at 3-6 months. Psychosocial interventions have the potential to improve MOUD treatment retention particularly when applied in combination in efficient delivery systems. The objective of this study is to develop an effective and efficient multicomponent intervention to increase buprenorphine retention at 6 months through an optimization trial.

Key Dates

First listed
May 26, 2026
Start date
Sep 30, 2026
Status verified
May 2026
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
240 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Behavioral Activation
    Participants in this arm will receive the behavioral activation intervention.
  • Experimental: Attendance Reinforcement
    Participants in this arm will receive the Attendance Reinforcement intervention.
  • Experimental: Peer-Delivered Motivational Interviewing
    Participants in this arm will receive the Peer-Delivered Motivational Interviewing Intervention.
  • Experimental: Behavioral Activation + Attendance Reinforcement
    Participants in this arm will receive the Behavioral Activation and Attendance Reinforcement interventions.
  • Experimental: Behavioral Activation + Peer-Delivered Motivational Interviewing
    Participants in this arm will receive the Behavioral Activation and Peer-Delivered Motivational Interviewing interventions.
  • Experimental: Attendance Reinforcement + Peer-Delivered Motivational Interviewing
    Participants in this arm will receive the Attendance Reinforcement and Peer-Delivered Motivational Interviewing interventions.
  • Experimental: Behavioral Activation + Attendance Reinforcement + Peer-Delivered Motivational Interviewing
    Participants in this arm will receive the Behavioral Activation, Attendance Reinforcement, and Peer-Delivered Motivational Interviewing interventions.
  • No Intervention: Treatment As Usual
    Participants randomized to this arm will receive usual care at their office based addiction treatment facility.

Primary Outcome Measure

Number of participants with buprenorphine retention [ Time Frame: 6 months ]

Central Contacts

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