Management of Age-Related Auditory Decline and Early Warning of Its Co-occurring Dementia

Sponsor
Chinese PLA General Hospital
Study ID
NCT07608640
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Age-related Hearing Loss
  • Dementia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Not applicable- observational study — OTHER
    Not applicable-observational study

Study Details

Against the backdrop of global population aging, age-related hearing loss (ARHL) has reached epidemic proportions and is increasingly recognized as an independent risk factor for cognitive decline and other major neurodegenerative diseases. This study aims to systematically develop an integrated framework for the early warning, precise assessment, and intervention management of ARHL. Using a national multicenter design, the project will establish a prospective cohort of more than 3,000 older adults. We will integrate multimodal data including audiological tests, cognitive function assessments, and blood biomarkers, and employ artificial intelligence and unsupervised machine learning methods to address critical bottlenecks in the field: the unclear mechanistic link between ARHL and cognitive decline, and the lack of validated predictive tools. Specifically, this study will: (1) develop data-driven clinical classification criteria for ARHL; (2) create a personalized "Hearing Health Clock" predictive model; (3) identify minimally invasive blood biomarkers for early detection of cognitive impairment; and (4) formulate a multidimensional early dementia screening program suitable for community-wide implementation. The findings will provide scientific evidence and practical tools for the prevention and control of hearing and cognitive health risks in older adults in China.

Key Dates

First listed
May 27, 2026
Start date
May 25, 2026
Status verified
May 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
3,000 participants (estimated)

Arms

  • Arm: Community-Dwelling Older Adults Group
    Older adults with bilaterally symmetric hearing and no middle ear abnormalities

Primary Outcome Measure

Incidence of dementia and cognitive decline, and progression of age-related auditory decline in community-dwelling older adults [ Time Frame: 3 years from baseline enrollment ]

Central Contacts

Related Studies