Yiqi Huoxue Jiedu Formula Combined With Bacteriophages in the Treatment of Severe Pneumonia

Sponsor
Chinese PLA General Hospital
Study ID
NCT07612605
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Pneumonia

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • YHDF placebo — DRUG
    7-14 days treatment with YHDF placebo
  • Bacteriophage Placebo — DRUG
    7-14 days treatment with bacteriophage placebo
  • YHDF Drug — DRUG
    7-14 days treatment with YHDF
  • Bacteriophage — DRUG
    7-14 days treatment with bacteriophage

Study Details

Through a prospective randomized controlled trial, we systematically evaluate the effects of Yiqi Huoxue Jiedu Formula combined with bacteriophage therapy on the bacterial clearance rate, disease improvement rate and mortality rate in patients with severe pneumonia caused by drug-resistant bacteria, so as to clarify its clinical transformation value.

Key Dates

First listed
May 29, 2026
Start date
Jun 1, 2026
Status verified
May 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2029

Study Design

Enrollment
250 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: YHDF Placebo + Bacteriophage Placebo Group
    7-14 days treatment with YHDF placebo, 7-14 days treatment with phage placebo
  • Active Comparator: YHDF Placebo + Bacteriophage Group
    7-14 days treatment with YHDF placebo, 7-14 days treatment with phage placebo
  • Active Comparator: YHDF Drug + Bacteriophage Placebo Group
    7-14 days treatment with YHDF, 7-14 days treatment with phage placebo
  • Active Comparator: YHDF Drug + Bacteriophage Group
    7-14 days treatment with YHDF, 7-14 days treatment with phage

Primary Outcome Measure

Clearance rate of drug-resistant bacteria [ Time Frame: 14 days ]

Central Contacts

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