Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions

Sponsor
Wroclaw Medical University
Study ID
NCT07617376
Phase
PHASE4
Status
Recruiting
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Conditions

  • Acute Heart Failure (AHF)
  • Arrhythmias
  • Decompensated Chronic Heart Failure
  • Hypertension Emergency
  • Myocardial Infarction
  • Pulmonary Embolism Acute

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Influenza vaccination — BIOLOGICAL
    Influenza vaccination pre-discharge in patients hospitalized for acute cardiac conditions

Study Details

Patients hospitalized for acute cardiac conditions-including acute myocardial infarction, acute heart failure, pulmonary embolism, arrhythmias, and hypertensive emergencies-represent a heterogeneous population at very high risk of recurrent cardiovascular events. Influenza infection may act as a trigger for adverse cardiovascular events. Given the persistently low influenza vaccination uptake despite evidence-based benefits observed in vulnerable populations, including patients with cardiac conditions, new strategies to improve vaccination coverage are being explored. Recently, increasing attention has been directed toward an approach already used in fields such as neonatology, where vaccinations are administered prior to hospital discharge. In this investigator-initiated, single-center, randomized, open-label interventional study, we will evaluate whether influenza vaccination administered within 24 hours before hospital discharge in patients hospitalized for acute cardiac conditions is safe and effective in reducing subsequent infections, cardiovascular events, and mortality during the 6 months following hospitalization.

Key Dates

First listed
Jun 1, 2026
Start date
Nov 12, 2025
Status verified
May 2026
Primary completion
Dec 31, 2026
Completion
Jul 1, 2027

Study Design

Enrollment
400 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • No Intervention: Standard of care
    standard of care (SOC), including recommendation for influenza vaccination in primary care
  • Experimental: Influenza vaccination pre-discharge in patients hospitalized for acute cardiac conditions
    pre-discharge influenza vaccine administration

Primary Outcome Measure

infection, unplanned cardiovascular hospitalization or cardiovascular death [ Time Frame: 6 months ]

Central Contacts

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