Multimodal mAgnetic Resonance imaGIng in Cardiovascular Disease

Sponsor
Second Affiliated Hospital, Zhejiang University, School of Medicine
Study ID
NCT07617844
Status
Recruiting
Apply to this trial

Conditions

  • Cardiomyopathy
  • Cardiovascular Diseases
  • Heart Valve Diseases
  • Ischemic Heart Disease (IHD)
  • Myocarditis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Multi-modal Cardiac Magnetic Resonance — DIAGNOSTIC_TEST
    A comprehensive "one-stop" scanning protocol using 3.0T MRI scanners. The protocol includes Cine imaging, T1/T2 mapping, Late Gadolinium Enhancement (LGE), first-pass perfusion, and 4D flow sequences to evaluate cardiac structure, function, myocardial tissue characteristics, and hemodynamics.

Study Details

This single-center, prospective, observational cohort study aims to evaluate the clinical application value of multi-modal cardiovascular magnetic resonance (CMR) imaging in patients with cardiovascular diseases (CVD). While traditional imaging methods have limitations in fully evaluating myocardial tissue characteristics, multi-modal CMR offers a comprehensive, non-invasive "one-stop" assessment. It can simultaneously evaluate heart structure, function, tissue features (such as fibrosis and edema), and hemodynamics. The study plans to enroll patients with suspected or confirmed CVD. Participants will undergo a comprehensive multi-modal CMR scan (including Cine, T1/T2 mapping, Late Gadolinium Enhancement, and 4D flow sequences) as part of their evaluation. In addition to clinical evaluation, the study will explore sequence optimization (e.g., comparing pre-contrast vs. post-contrast Cine, and 3-slice vs. 9-slice T1 mapping) and evaluate deep learning-based virtual native enhancement (VNE) models trained under different sequence protocols. By tracking clinical outcomes, the study seeks to establish a standardized imaging assessment system to improve the early detection, accurate diagnosis, risk stratification, and prognostic prediction for various types of cardiovascular diseases.

Key Dates

First listed
Jun 1, 2026
Start date
Jan 1, 2026
Status verified
May 2026
Primary completion
Dec 31, 2028
Completion
Dec 31, 2028

Study Design

Enrollment
2,000 participants (estimated)

Primary Outcome Measure

Diagnostic Efficacy of Multi-modal CMR Parameters (AUC) [ Time Frame: Baseline (at the time of CMR scan) ]

Central Contacts

Related Studies