Impact of rTMS on Abnormal Cortical fMRI in Patients With Dystonia

Part of paid clinical trials in Manhasset, New York.

Sponsor
Northwell Health
Study ID
NCT07626216
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Dystonia Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Magnetic Stimulation — DEVICE
    Continuous theta-burst stimulation (cTBS), a modified form of rTMS that mimics natural brain rhythms (theta 4-8Hz), can effectively inhibit the cortical hyperactivity in targeted hubs with shorter treatment times than traditional approaches. The rationale for this proposed pilot experiment is to combine advanced analysis of standard neuroimaging to refine target location for a test of whether the application of non-invasive rTMS (in the form of cTBS) modulates abnormal cortical regions or the entire brain network, or both, as these networks underlie dystonia. This pilot study will provide the basis for a controlled study to test the effectiveness and robustness of any positive influence that TMS might have on the patients' dystonia.

Study Details

By tracking resting-state fMRI scans, we aim to discover how repetitive transcranial magnetic stimulation (rTMS) changes brain connectivity in individuals with dystonia.

Key Dates

Start date
Mar 4, 2026
Status verified
May 2026
Primary completion
May 31, 2028
Completion
May 31, 2029

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Active rTMS Arm
    We will investigate how repetitive transcranial magnetic stimulation (rTMS) affects brain networks in patients with dystonia by measuring changes in resting state-functional magnetic resonance images (rs-fMRI).

Primary Outcome Measure

Evaluating rs-fMRI Changes Following rTMS Treatment [ Time Frame: Two to four weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIP
Northwell Health/Feinstein InstitutesManhassetNew York11030

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Northwell Health/Feinstein Institutes· Manhasset, NY

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