Single and Multiple Dose Study to Evaluate Safety and Pharmacokinetics of BMS-986533 in Healthy Participants and Assessments of Food and pH Effects on Relative Bioavailability, and Drug-Drug Interaction Potential in Healthy Participants

Part of paid clinical trials in Lincoln, Nebraska.

Sponsor
Bristol-Myers Squibb
Study ID
NCT07629999
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Healthy Volunteers

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • BMS-986533 — DRUG
    Specified dose on specified days
  • Famotidine — DRUG
    Specified dose on specified days
  • Placebo — DRUG
    Specified dose on specified days
  • Dabigatran Etexilate — DRUG
    Specified dose on specified days
  • Rosuvastatin — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the safety and pharmacokinetics of BMS-986533 in healthy participants receiving single and multiple doses, to assess food and pH effects on the relative bioavailability of BMS-986533, and the P-gp and BCRP-mediated drug-drug interaction potential of the study drug

Key Dates

Start date
Jun 30, 2026
Status verified
May 2026
Primary completion
Jun 1, 2027
Completion
Jun 1, 2027

Study Design

Enrollment
118 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A
  • Experimental: Arm B
  • Experimental: Arm C
  • Experimental: Arm D

Primary Outcome Measure

Number of participants with Adverse Events (AE) [ Time Frame: Up to Day 47 ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (1)

FacilityCityStateZIP
Local Institution - 0001LincolnNebraska68502

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Local Institution - 0001· Lincoln, NE

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