Vascular Function in Adults With Down Syndrome

Part of paid clinical trials in Las Vegas, Nevada.

Sponsor
University of Nevada, Las Vegas
Study ID
NCT07630207
Status
Recruiting
Apply to this trial

Conditions

  • Down Syndrome (Trisomy 21)

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Study Details

Adults with Down syndrome (Ds) are often thought to have a lower risk of heart and blood vessel disease because they tend to have lower blood pressure and fewer heart attacks than people without Ds. However, recent research suggests that heart and blood vessel diseases, including stroke, are becoming a more common cause of death in adults with Ds as life expectancy increases. Despite these findings, studies examining heart and blood vessel health in adults with Ds have produced mixed results, making it difficult to determine their true risk and whether preventive strategies are needed. This study will investigate the health of blood vessels in adults with Ds and compare the results with those of adults without Ds. Healthy blood vessels are important because they help deliver blood and oxygen throughout the body. Changes in blood vessel function and stiffness can occur with aging and may increase the risk of heart disease, stroke, kidney disease, and memory problems. The study aims to determine whether adults with Ds experience changes in blood vessel health that may place them at increased cardiovascular risk. Specifically, the study will: (1) Examine how well blood vessels function in adults with Ds; (2) Measure the stiffness of arteries in adults with Ds; (3) Compare two methods used to assess blood vessel function to determine whether a simpler exercise-based test provides results similar to a commonly used standard test. The findings may improve understanding of cardiovascular risk in adults with Ds and help guide future strategies to promote healthy aging in this population.

Key Dates

Start date
Apr 9, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
24 participants (estimated)

Arms

  • Arm: Down Syndrome
    Adults with Down Syndrome
  • Arm: Control group
    Age- and sex-matched adults without Down Syndrome

Primary Outcome Measure

Carotid-femoral pulse wave velocity (PWV). [ Time Frame: Through study completion, on average 4 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIP
University of Nevada Las Vegas - UNLVLas VegasNevada89154

Find similar trials in Las Vegas, NV

By research site
University of Nevada Las Vegas - UNLV· Las Vegas, NV

Related Studies