MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation

Conditions

• Atrial Flutter With Rapid Ventricular Response

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Magnesium Sulfate 2g — DRUG
  Magnesium Sulfate 2g for the treatment of atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR)
• Magnesium Sulfate 4g — DRUG
  Magnesium Sulfate 4g for the treatment of atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR)
• Saline (0.9% NaCl) — DRUG
  The control group will receive a bolus of normal saline of the same volume and infused over 15 minutes.

Study Details

The purpose of this research study is to find out if the use of magnesium in addition to Metoprolol, a rate controlling medication that you would be offered in the Emergency Department today unrelated to this study, will help reduce your high heart rate (rapid ventricular response).

Key Dates

Start date

Jun 30, 2026

Status verified

May 2026

Primary completion

Dec 31, 2028

Completion

Dec 31, 2028

Study Design

Enrollment

196 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Experimental Arm One, Magnesium Sulfate 2g followed by metoprolol 5 mg
  Study drug (Magnesium Sulfate 2 gram/50ml 0.9% NaCl) will be administered over a time interval of 15 minutes. Immediately after study drug administration, intravenous metoprolol 5 mg will be administered as an IV push over 2 minutes. Additional doses of metoprolol 5 mg as an IV push over 1 minute permissible, however additional doses of study drug will not be administered. Emergency Medicine physician may provide additional doses of intravenous metoprolol every 5 minutes based on clinical necessity.
• Experimental: Experimental Arm Two, Magnesium Sulfate 4g followed by metoprolol
  Study drug (Magnesium Sulfate 4 gram/50ml 0.9% NaCl) will be administered over a time interval of 15 minutes. Immediately after study drug administration, intravenous metoprolol 5 mg will be administered as an IV push over 2 minutes. Additional doses of metoprolol 5 mg as an IV push over 1 minute permissible, however additional doses of study drug will not be administered. Emergency Medicine physician may provide additional doses of intravenous metoprolol every 5 minutes based on clinical necessity.
• Placebo Comparator: Control Arm, normal saline followed by metoprolol
  50ml 0.9% NaCl will be administered over a time interval of 15 minutes. Intravenous metoprolol 5 mg will be immediately administered as an IV push over 2 minutes. Additional doses of metoprolol 5 mg as an IV push over 1 minute permissible, however additional doses of saline will not be administered. Emergency Medicine physician may provide additional doses of intravenous metoprolol every 5 minutes based on clinical necessity.

Primary Outcome Measure

Ventricular rate control [ Time Frame: Within the first 2 hours of intravenous magnesium administration ]

Central Contacts

• Marc McDowell, PharmD
  (708) 684-1078
  [email protected]
• Thomas Szwajnos
  [email protected]

Locations (1)

Find similar trials in Oak Lawn, IL

Related Studies

• Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
  PHASE3 · Recruiting · Wake Forest University Health Sciences · Oak Lawn, Illinois