Phenotype Guided Vasoactive Medication During Kidney Transplantation

Part of paid clinical trials in Los Angeles, California.

Sponsor
Jennifer Cutler
Study ID
NCT07633600
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Fluid Management
  • Kidney Transplant

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Phenotype-Guided Vasoactive Management — DRUG
    Recipients undergo intraoperative circulation phenotyping using pulse contour monitoring and flow-pressure coupling testing. Vasoactive support is assigned according to phenotype: vasopressin infusion for Hyperdynamic physiology, norepinephrine infusion for Mixed Physiology, calcium chloride and/or low-dose dopamine for Poor Contractility, and fluid-guided support for Normal physiology.

Study Details

The goal of this clinical trial is to learn if vasopressin improves the body's response to intravenous fluids during kidney transplantation in patients who have relaxed blood vessels. Researchers will compare the results of vasopressin to those who received calcium chloride.

Key Dates

Start date
Jun 1, 2026
Status verified
Jun 2026
Primary completion
Jun 1, 2027
Completion
Dec 1, 2027

Study Design

Enrollment
255 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: Experimental: Phenotype-Guided Vasoactive Protocol
    Recipients undergo intraoperative circulation phenotyping using pulse contour monitoring and fluid responsiveness testing. Vasoactive support is assigned according to phenotype: vasopressin infusion for Hyperdynamic physiology, norepinephrine infusion for Mixed Physiology, calcium chloride and/or low-dose dopamine for Poor Contractility, and fluid-guided support for Normal physiology.

Primary Outcome Measure

Positive Flow-Pressure Coupling Proportion in Hyperdynamic Phenotype as measured by pulse contour analysis on the Edwards Hemosphere [ Time Frame: Intraoperative (from induction to end of surgery) ]

Central Contacts

Locations (1)

FacilityCityStateZIP
Cedars Sinai Medical CenterLos AngelesCalifornia90048

Find similar trials in Los Angeles, CA

By research site
Cedars Sinai Medical Center· Los Angeles, CA

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