Discovering Determinants of Food Intake by Application of Artificial Intelligence to Complex, High-Dimensional Data

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Study ID
NCT07637656
Status
Not Yet Recruiting

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Conditions

  • Healthy Volunteer

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Study Details

Background: Many people in the United States are overweight or obese. Researchers want to learn why some people can overeat and not gain weight, whereas others who do not overeat still gain weight. Objective: To study factors related to food intake that can lead to weight gain over time. Eligibility: Healthy adults aged 18 to 60 years. Design: Participants will have 6 to 8 clinic visits over 2 years. The first 3 or 4 study visits will be 1 week apart. Procedures during visits may include the following: Collection of blood, hair, urine, and stool samples. Measurement of the waist, neck, thighs, and other parts of the body. Dual energy x-ray absorption (DXA) scan: Participants will lie still on a padded table while they are scanned to measure body fat. Physical activity monitor: Participants will wear a monitor on the wrist for 2 weeks. Cognitive tests: Participants will perform tasks to measure attention, memory, and brain function. Continuous glucose monitor. Participants will wear a device that measures their blood glucose for 1 week. Mixed meal test and stomach emptying test. Participants will drink a breakfast shake and swallow a dose of acetaminophen. Blood will be drawn over the next 4 hours. Resting metabolic rate: Participants will wear a clear hood over their head while they rest for 20 minutes. The hood will measure the gases they breathe. Breakfast and lunch test. Participants will eat a standard breakfast. They will be allowed to select from foods and eat as much as they like at lunch. They will be asked how hungry or full they are. Questionnaires. Participants will answer questions about their health, sleep, physical activity, and eating.

Key Dates

Start date
Jun 15, 2026
Status verified
Jun 2026
Primary completion
Jul 1, 2037
Completion
Jul 1, 2037

Study Design

Enrollment
800 participants (estimated)

Arms

  • Arm: 1
    800 males and females, age 18-60 years who are in good health

Primary Outcome Measure

To identify novel determinants of objectively measured ad libitum energy intake using broad, multiscale data. [ Time Frame: 24-28 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
NIDDK, Phoenix, 850 N. 5th Street 7th FloorPhoenixArizona85004
Susanne Votruba, Ph.D.
[email protected]
301-827-3521

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By research site
NIDDK, Phoenix, 850 N. 5th Street 7th Floor· Phoenix, AZ

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