A Study of MSK-TCR5 in People With Solid Tumor Cancers

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT07638371
Phase
PHASE1
Status
Not Yet Recruiting

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Conditions

  • Advanced Solid Tumor
  • Metastatic Solid Tumor
  • Solid Carcinoma
  • Solid Tumor
  • Unresectable Solid Tumor

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • MSK-TCR5 — BIOLOGICAL
    MSK-TCR5, created in participant-derived T cells and autologously reinfused into eligible participants following lymphodepleting chemotherapy

Study Details

The purpose of this study is to test the safety of MSK-TCR5 in participants with advance solid tumor cancer that has a KRAS, HRAS, or NRAS G12D mutation.

Key Dates

Start date
Jul 31, 2026
Status verified
Jun 2026
Primary completion
Jul 31, 2030
Completion
Jul 31, 2030

Study Design

Enrollment
16 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Dose Level 1: 1.0 x 10^10 Cell Dose (cell number)
  • Experimental: Dose Level 2: 3.0 x 10^10 Cell Dose (cell number)
  • Experimental: Dose Level 3: 0.3 to 1.0 x 10^11 Cell Dose (cell number)
  • Experimental: Dose Level -1: 3.0. x 10^9 Cell Dose (cell number)

Primary Outcome Measure

Number of related toxicities [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited Protocol Activities)CommackNew York11725
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Adam Schoenfeld, MD
646-608-4042
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Lauren Schaff, MD
212-610-0485
Memorial Sloan Kettering Cancer Center @ Nassau (Limited Protocol Activities)UniondaleNew York11553
Adam Schoenfeld, MD
646-608-4042

Find similar trials in Basking Ridge, NJ

By research site
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

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