EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery

Sponsor
Konya City Hospital
Study ID
NCT07642765
Status
Not Yet Recruiting

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Conditions

  • Anesthesia, General
  • Frailty
  • Hypotension on Induction

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • EASIX Score Assessment — OTHER
    Preoperative Endothelial Activation and Stress Index (EASIX) score calculated from routine laboratory parameters obtained within 24 hours before surgery. Formula: LDH (U/L) × Creatinine (mg/dL) / Platelet count (10⁹/L). No additional blood sampling is performed; only existing routine preoperative laboratory values are used.

Study Details

Post-induction hypotension (PIH) is a common and clinically significant hemodynamic complication following general anesthesia induction. Frail patients are particularly vulnerable due to impaired vascular reactivity and endothelial dysfunction. The Endothelial Activation and Stress Index (EASIX), calculated from routine laboratory parameters (LDH, creatinine, and platelet count), may serve as a preoperative biomarker to identify patients at risk for PIH. This prospective observational cohort study aims to evaluate the association between preoperative EASIX score and the occurrence of post-induction hypotension in frail patients undergoing elective non-cardiac surgery under general anesthesia. A total of 160 patients with a Clinical Frailty Scale (CFS) score of 4 or above will be enrolled. Mean arterial pressure will be measured every 2 minutes for the first 15 minutes after induction. PIH is defined as MAP below 65 mmHg and/or a decrease of 20% or more from baseline.

Key Dates

First listed
Jun 11, 2026
Start date
Jul 1, 2026
Status verified
Jul 2026
Primary completion
Feb 1, 2027
Completion
Mar 1, 2027

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: Frail Patients Undergoing Non-Cardiac Surgery
    Adult patients aged 18 years or older with a Clinical Frailty Scale (CFS) score of 4 or above, scheduled for elective non-cardiac surgery under general anesthesia at Konya City Hospital. Preoperative EASIX score will be calculated from routine laboratory values (LDH, creatinine, platelet count) obtained within 24 hours before surgery. Post-induction hemodynamic data will be collected for the first 15 minutes after anesthesia induction.

Primary Outcome Measure

Incidence of Post-Induction Hypotension [ Time Frame: Within the first 15 minutes after anesthesia induction ]

Central Contacts

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