Multivitamin and Mineral Supplementation and Healthy Aging

Part of paid clinical trials in La Jolla, California.

Sponsor
University of California, San Diego
Study ID
NCT07642869
Status
Recruiting
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Conditions

  • Healthy Aging
  • Multivitamin and Mineral Supplementation

Eligibility Criteria

Sex
ALL
Age
40 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • MVM Core Blend — DIETARY_SUPPLEMENT
    Consists of a pill containing a 22-ingredient blend of vitamins and minerals 1 pill will be taken daily, 7 days/week for 12 weeks
  • MVM Gold Blend — DIETARY_SUPPLEMENT
    Pills, participants will take contain a 17-ingredient blend of vitamins and minerals. Instructions: 1 pill each day, 7 days/week for 12 weeks
  • Placebo — DIETARY_SUPPLEMENT
    Pill contains no vitamins or minerals. 1 pill will be taken daily, 7 days/week, for 12 weeks

Study Details

The goal of this study is to determine the impact of MVM supplementation on clinical and biochemical markers associated with healthy aging, with a particular focus on mitochondrial function and metabolism. Specifically, changes in mitochondrial respiration using isolated blood cells will be measured. This method has been used to compare with various other age-related markers of health such as physical function, gait speed, and resting metabolic rate. It is hypothesize that MVM supplementation will impact the function of blood cells. We will also explore how MVM supplementation impacts other markers of health, including serum nutrient levels, metabolomic profiles, physical function, and skeletal muscle composition and quality. These comprehensive assessments will provide insights into the potential benefits of MVM supplementation for healthy aging and address critical gaps in our understanding of its immediate effects. Further, this study will aid in the understanding of how multivitamin supplements can support heathy aging in mid-life adults, a key time to start including wellness programs in our lives. The study cohort will consist of 150 sedentary men and women aged 40-60-years of age. A double-blind, three-arm, placebo-controlled randomized clinical trial will be conducted. Participants will receive a daily oral tablet containing one of two possible formulations of vitamins and minerals or a placebo. The three groups will be MVM "GOLD" blend formula, the US Restage MVM "US CORE", and the placebo group.

Key Dates

Start date
Sep 5, 2025
Status verified
Jun 2026
Primary completion
Oct 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: MVM Core Blend
    This is a modification to currently marketed Centrum Adult in which select nutrients have been removed or lowered to provide a better consumer experience. This will be consumed once per day for the duration of the study.
  • Experimental: MVM Gold Blend
    Because Centrum is a global multivitamin/multimineral brand, it has numerous product formulations for different regions/markets around the world. To better harmonize these formulations across key markets, a 'core' blend of vitamins and minerals has been designed at levels that can be leveraged across different markets - this is internally being referred to as the MVM "GOLD" Blend formula. This will be consumed once per day for the duration of the study.
  • Placebo Comparator: Placebo
    The placebo is a pill of the same color, size, and density as the experimental pills. It contains no vitamins or minerals. It will be administered once a day as the experimental pills.

Primary Outcome Measure

PBMC Respiratory Capacity by Oxymetry [ Time Frame: From enrollment to the end of study at 14 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, San DiegoLa JollaCalifornia92093
Lina Scandalis, PhD
[email protected]
18588226443
David Wing, PhD
[email protected]
Anthony Molina, PhD (PRINCIPAL_INVESTIGATOR)

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