Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients

Sponsor
Hospital Las Higueras
Study ID
NCT07643597
Status
Recruiting
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Conditions

  • Acute Kidney Injury
  • Critical Illness
  • Fluid Overload
  • Fluid Overload in Dialysis Patients
  • Renal Replacement Therapy for Acute Kidney Injury in ICU

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes. Continuous renal replacement therapy (CRRT) allows fluid removal through net ultrafiltration (UFNET), but some patients develop hemodynamic instability or signs of poor tissue perfusion during this process. The purpose of this prospective observational study is to evaluate tolerance to net ultrafiltration in critically ill patients with AKI receiving CRRT. The study will assess clinical, hemodynamic, ultrasound, perfusion, and biochemical parameters before and during fluid removal to identify factors associated with ultrafiltration intolerance. The investigators hypothesize that alterations in hemodynamic, perfusion, and congestion-related parameters can identify patients at increased risk of ultrafiltration intolerance before the development of overt hypotension. The results may help improve individualized fluid removal strategies and optimize the safety of CRRT in critically ill patients.

Key Dates

First listed
Jun 11, 2026
Start date
Jul 6, 2026
Status verified
Jul 2026
Primary completion
Dec 1, 2027
Completion
Dec 1, 2027

Study Design

Enrollment
128 participants (estimated)

Arms

  • Arm: AKI Patients Receiving CRRT With Net Ultrafiltration
    Adult critically ill patients with acute kidney injury receiving continuous renal replacement therapy with prescribed net ultrafiltration. Participants will be prospectively evaluated using a multiparametric monitoring strategy including clinical, hemodynamic, ultrasound, perfusion, and biochemical assessments. Patients will subsequently be classified according to the development or absence of ultrafiltration intolerance during the observation period.

Primary Outcome Measure

Development of Ultrafiltration Intolerance [ Time Frame: From UFNET initiation (T0) to 24 hours after initiation of net ultrafiltration ]

Central Contacts

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