Feasibility and Effects of Noninvasive Brain Stimulation on Pain Perception in People With Fibromyalgia

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Pulkit Grover
Study ID
NCT07644221
Status
Not Yet Recruiting

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Conditions

  • Fibromyalgia (FM)

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Primary Motor Cortex Stimulation — DEVICE
    Short (\<1 ms), high amplitude (\>10 mA) noninvasive electrical pulses delivered at 1 Hz on the scalp surface. This intervention will target the primary motor cortex (M1).
  • Occipital Lobe Stimulation — DEVICE
    Short (\<1 ms), high amplitude (\>10 mA) noninvasive electrical pulses delivered at 1 Hz on the scalp surface. This intervention will target the occipital lobe.

Study Details

The goal of this interventional study is to learn whether noninvasive brain stimulation (NIBS) will have an effect on pain perception in people with fibromyalgia. The main questions it aims to answer are: Do repeated sessions of NIBS lead to a reduction in perceived pain? Do repeated sessions of NIBS lead to an improvement in quality of life? Researchers will compare different brain targets to see if effects are different between them. Participants will receive repeated daily sessions of NIBS over 4 weeks with application of pressure pain algometry, and complete various questionnaires.

Key Dates

Start date
Jun 30, 2026
Status verified
Jun 2026
Primary completion
May 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Primary Motor Cortex Stimulation, then Occipital Lobe Stimulation
    The primary motor cortex will be targeted first, then the occipital lobe.
  • Experimental: Occipital Lobe Stimulation, then Primary Motor Cortex Stimulation
    The occipital lobe will be targeted first, then the primary motor cortex.

Primary Outcome Measure

Feasibility of the transcranial electrical stimulation protocol [ Time Frame: From end of the last study session until up to 6 months after. ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Carnegie Mellon UniversityPittsburghPennsylvania15213
Pulkit Grover, PhD
[email protected]
412-268-3644
Jeehyun Kim, MS
[email protected]
248-619-4271
UPMC Pain ManagementPittsburghPennsylvania15206
Benedict J Alter, MD, PhD
[email protected]
412-677-0575
Emma Racunas, BS
[email protected]

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By research site
Carnegie Mellon University· Pittsburgh, PAUPMC Pain Management· Pittsburgh, PA

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