Interactive Effects of Sodium and Potassium on Vascular Health in Older Adults

Conditions

• Healthy Older Adults

Eligibility Criteria

Sex

ALL

Age

55 Years - 75 Years

Healthy Volunteers

Accepted

Interventions

• low sodium/low potassium diet — OTHER
  On this intervention, participants will be given a diet that provides 2,000 mg Na/day and 2,000 mg K/day
• high sodium/low potassium diet — OTHER
  On this intervention, participants will be given a diet that provides 4,700 mg Na/day and 2,000 mg K/day
• high sodium/high potassium diet — OTHER
  On this intervention, participants will be given a diet that provides 4,700 mg Na/day and 4,700 mg K/day

Study Details

The goal of this clinical trial is to determine if a high potassium intake can counteract the harmful effects of excess sodium on endothelial function in older adults with no history of cardiometabolic disease. The main questions it aims to answer are: 1. Can a high potassium intake attenuate dietary sodium-induced endothelial dysfunction in older adults. 2. Do changes in endothelial function in response to alterations in sodium and potassium intake differ by sex. Participants will participants will consume three controlled diets for 10 days each with a minimum 14-day washout between interventions. The order in which participants consume the diets will be randomized. The study diets will vary in sodium and potassium content. Measures of cardiovascular health (blood pressure, arterial stiffness, endothelial function) will be assessed at the end of each diet.

Key Dates

Start date

Mar 24, 2026

Status verified

Jun 2026

Primary completion

Jun 30, 2027

Completion

Jun 30, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Arms

• Experimental: low Na/low K, high Na/low K, high Na/high K
  Three 10-day controlled diets in randomized order, each varying in sodium and potassium content. There is a minimum 2-week washout between diets.
• Experimental: low Na/low K, high Na/high K, high Na/low K
  Three 10-day controlled diets in randomized order, each varying in sodium and potassium content. There is a minimum 2-week washout between diets.
• Experimental: high Na/high K, low Na/low K, high Na/low K
  Three 10-day controlled diets in randomized order, each varying in sodium and potassium content. There is a minimum 2-week washout between diets.
• Experimental: high Na/high K, high Na/low K, low Na/low K
  Three 10-day controlled diets in randomized order, each varying in sodium and potassium content. There is a minimum 2-week washout between diets.
• Experimental: high Na/low K, low Na/low K, high Na/high K
  Three 10-day controlled diets in randomized order, each varying in sodium and potassium content. There is a minimum 2-week washout between diets.
• Experimental: high Na/low K, high Na/high K, low Na/low K
  Three 10-day controlled diets in randomized order, each varying in sodium and potassium content. There is a minimum 2-week washout between diets.

Primary Outcome Measure

Endothelial function [ Time Frame: "Day 11" after each of the three 10-day dietary interventions ]

Central Contacts

• Andrea Lobene
  850-644-1829
  [email protected]
• FSU Ann's College
  850-644-6685

Locations (1)

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