Congenital Hemolytic and Dyserythropoietic Anemias

Conditions

• Hemolytic Anemia

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Not accepted

Study Details

The main reason for this research study is to further understand how some red blood cells are formed incorrectly or they have an abnormal metabolism in a way that they break easier in the circulation or during their passage through the spleen. Participants and/or family members diagnosed with non-immune hemolytic anemia due to a genetic disorder, such as, hemoglobin disorder, erythrocyte membrane skeleton disorders (e.g. spherocytosis, elliptocytosis, or stomatocytosis) or hydration defect (e.g. xerocytosis, overhydrocytosis) or red blood cell (RBC) enzyme disorders, or with a congenital dyserythropoietic anemia (CDA) will be asked to participate.

Key Dates

Start date

Jul 25, 2011

Status verified

Jun 2026

Primary completion

Jul 31, 2050

Completion

Jul 31, 2052

Study Design

Enrollment

400 participants (estimated)

Primary Outcome Measure

Percentage of Participants with an Established Molecular Diagnosis of a Red Blood Cell Disorder [ Time Frame: From enrollment to completion of molecular and diagnostic evaluation (approximately 12-24 months) ]

Central Contacts

• Amy Shova
  513-803-1917
  [email protected]

Locations (1)

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