Significance of Estrogen Status for Muscle Function, Physical Fitness, and Physiological Health Parameters - a Comparison of Age-matched Groups of Women Before and After Menopause.

Conditions

• Menopause
• Muscle Mass and Strength

Eligibility Criteria

Sex

FEMALE

Age

47 Years - N/A

Healthy Volunteers

Accepted

Study Details

As females age and transition through menopause, the decline in oestrogen level profoundly affects skeletal muscle mass and function. HER-MUSCLE aims to unravel the differences in pre and post menopausal women, in regards to muscle size, strength and function. Focusing on postmenopausal females, an increasingly at-risk demographic, HER-MUSCLE addresses a critical gap in understanding how oestrogen influences muscle mass and function. The project involves: 1. Molecular Analysis: Advanced techniques will study the muscle microenvironment, focusing on muscle stem cells (MuSCs), fibro-adipogenic progenitors (FAPs), and other cells critical for muscle regeneration and maintenance. 2. Mitochondrial Function assessed in vivo via magnetic resonance spectroscopy: The impact of oestrogen on mitochondrial health will be examined, exploring how it preserves mitochondrial function and ability to recovery and resist fatigue in response to muscle contractions. Our preliminary data indicate that oestrogen can promote muscle protein synthesis. HER-MUSCLE aims to pave the way for novel therapeutic strategies to manage sarcopenia in postmenopausal women, ultimately leading to better health outcomes and enhanced well-being for this growing population segment.

Key Dates

First listed

Jun 16, 2026

Start date

Feb 1, 2026

Status verified

Jun 2026

Primary completion

Aug 1, 2027

Completion

Aug 1, 2027

Study Design

Enrollment

30 participants (estimated)

Arms

• Arm: Post menopausal women
• Arm: Pre menopausal women

Primary Outcome Measure

Muscle mass [ Time Frame: 1 week ]

Central Contacts

• Mette Hansen, PhD
  +4551666551
  [email protected]

Find similar trials

Related Studies

• Apple Women's Health Study
  Recruiting · Apple Inc. · Boston, Massachusetts
• Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
  Recruiting · University of Minnesota · Minneapolis, Minnesota
• Hot Flashes and Neurovascular Function in Women
  Recruiting · Mayo Clinic · Rochester, Minnesota
• The Cardiovascular Impact of Hot Flushes
  Recruiting · University of Minnesota · Minneapolis, Minnesota