Postprandial Effects of Fresh Mango as a Table Sugar Replacement in High-Sugar Breakfasts.

Part of paid clinical trials in Muncie, Indiana.

Sponsor
Ball State University
Study ID
NCT07650058
Status
Recruiting
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Conditions

  • Healthy Participants

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • High-Glycemic Breakfast Containing Cereal and Fresh Mango — OTHER
    High-glycemic breakfast of 84 grams of corn flakes prepared with 355 mL of 2% milk and sweetened with 262 grams of fresh mango.
  • High-Glycemic Breakfast Containing Cereal and Table Sugar — OTHER
    High-glycemic breakfast of 84 grams of corn flakes prepared with 355 mL of 2% milk and sweetened with 36 grams of table sugar.

Study Details

Systemic inflammation and intestinal hyperpermeability (disruption of the gut barrier which allows nutrient molecules and bacteria to enter the bloodstream) are triggered by consumption of high-sugar meals and are linked to future development of cardiovascular disease (CVD). Previous research indicates that fresh mangos have properties that have positive effects on the intestinal barrier and local gut inflammation. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to decreased inflammatory and permeability biomarkers after eating a high-sugar breakfast. The investigators will compare the postprandial (post meal) levels of inflammatory (IL-6) and permeability (LPS, lipid binding protein (LBP), and soluble CD14) biomarkers in blood from participants who have consumed a meal sweetened with either sucrose or fresh mango.

Key Dates

Start date
Feb 1, 2026
Status verified
Jun 2026
Primary completion
Jul 31, 2026
Completion
Jan 31, 2027

Study Design

Enrollment
35 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Cereal Consumption with Fresh Mango
    During the Cereal and Fresh Mango arm, participants will consume a bowl of corn flakes with 2% milk sweetened with fresh mango.
  • Experimental: Cereal Consumption with Table Sugar
    During the Cereal and Table Sugar arm, participants will consume a bowl of corn flakes with 2% milk sweetened with table sugar.

Primary Outcome Measure

LPS [ Time Frame: Through study completion, up to 1 year. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Health Professions Building, Ball State UniversityMuncieIndiana47306
Bryant Keirns, PhD
[email protected]
765-285-8356

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By research site
Health Professions Building, Ball State University· Muncie, IN

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