Impact of Culture of Perfusion Fluid on Donor-derived Infection Management and Outcome in Liver and Kidney Transplant

Sponsor
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study ID
NCT07651137
Status
Not Yet Recruiting

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Conditions

  • Bacterial Infection
  • Donor-derived Infection
  • Kidney Transplant
  • Kidney Transplant Infection
  • Liver Transplant
  • Liver Transplant Infection

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

This study aims to evaluate whether microbiological testing of the perfusion fluid used to transport transplanted organs can help predict the development of infections in liver and kidney transplant recipients, including possible donor-derived infections (infections transmitted from the donor organ). The study will include all liver and kidney transplant recipients with available perfusion fluid culture results from 2021 until the start of the study (retrospective phase) and for two years after study initiation (prospective phase). The study will assess how often high-risk microorganisms are identified in perfusion fluid, whether these findings are associated with complications or infections in recipients, and whether they affect patient outcomes, including mortality.

Key Dates

First listed
Jun 16, 2026
Start date
Sep 1, 2026
Status verified
Jun 2026
Primary completion
Feb 28, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
1,400 participants (estimated)

Arms

  • Arm: Adult patients (≥18 years old) undergoing liver or kidney transplantation at IRCCS AOUBO
    Adult patients (≥18 years old) undergoing liver or kidney transplantation at IRCCS AOUBO clinical center during the specified study periods

Primary Outcome Measure

To evaluate the clinical impact of high-risk perfusion fluid cultures in terms of infectious complications [ Time Frame: At 30, 90, and 180 days post-transplant ]

Central Contacts

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