Near-Infrared Spectroscopy, Acute Taurine Supplementation, and Isolated Muscular Endurance and Fatigue Resistance in Young Healthy Adults

Conditions

• Acute Taurine Supplementation
• Local Muscular Endurance and Fatigue
• NIRS Skeletal Muscle Mitochondrial Capacity

Eligibility Criteria

Sex

ALL

Age

18 Years - 40 Years

Healthy Volunteers

Accepted

Interventions

• Acute Taurine Supplementation — DIETARY_SUPPLEMENT
  Participants will ingest six taurine capsules (6 grams of taurine) following a baseline blood collection to determine baseline plasma taurine levels. 60 minutes following ingestion, there will be an additional blood collection to determine post-supplementation plasma taurine levels. Participants will then perform exercise assessments. The order of taurine supplementation relative to placebo supplementation will be randomized in a double-blind crossover with 7-10 days separating each condition.
• Acute Placebo Supplementation — DIETARY_SUPPLEMENT
  Participants will ingest six placebo capsules (1.2 grams of microcrystalline cellulose) following a baseline blood collection to determine baseline plasma taurine levels. 60 minutes following ingestion, there will be an additional blood collection to determine post-supplementation plasma taurine levels. Participants will then perform exercise assessments. The order of placebo supplementation relative to taurine supplementation will be randomized in a double-blind crossover with 7-10 days separating each condition.

Study Details

The goal of this clinical trial is to determine the association between near-infrared spectroscopy (NIRS)-derived mitochondrial oxidative phosphorylation (OXPHOS) capacity of the vastus lateralis muscles, and both local muscular endurance capacity and local muscular fatigability of the thigh muscles in young adults. Additionally, this trial aims to determine the effect of acute taurine supplementation on local muscular endurance capacity and local muscular fatigability when compared to a placebo condition. The main questions it aims to answer are: 1. Will there be a positive correlation between NIRS rate constant (a marker of mitochondrial function) and local muscular endurance capacity, along with a negative correlation between NIRS rate constant and local muscular fatigability? 2. Will acute taurine supplementation lead to improvements in local muscular endurance capacity and local muscular fatigability when compared to a placebo condition? Participants will: 1. Complete a NIRS assessment to non-invasively assess the mitochondrial capacity of both vastus lateralis muscles 2. Complete two acute supplementation assessment visits (separated by 7-10 days) which involve small blood collections before and after taurine or placebo supplementation 3. Perform a single-leg extension time-to-exhaustion test to measure local muscular endurance capacity on one leg, along with a repeated maximal voluntary isometric contraction fatigue index test to measure local muscular fatigability on the opposite leg, during each acute supplementation assessment visit.

Key Dates

First listed

Jun 17, 2026

Start date

Jul 15, 2026

Status verified

Aug 2026

Primary completion

Jan 15, 2027

Completion

Jan 15, 2027

Study Design

Enrollment

34 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Acute Taurine Supplementation
  Participants will ingest six taurine capsules (6 grams of taurine)
• Placebo Comparator: Acute Placebo Supplementation
  Participants will ingest six placebo capsules (1.2 grams of microcrystalline cellulose)

Primary Outcome Measure

Single Leg Extension Time-to-Exhaustion [ Time Frame: From Acute Supplementation Assessment Visit 1 to Acute Supplementation Assessment Visit 2, 7-10 days ]

Central Contacts

• Efthymios Papadopoulos, PhD
  225-578-0938
  [email protected]
• Carlante Emerson, MS
  225-733-4693
  [email protected]

Locations (1)

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