A Clinical Study of MK-8527 in Healthy Participants (MK-8527-021)

Part of paid clinical trials in Daytona Beach, Florida.

Sponsor
Merck Sharp & Dohme LLC
Study ID
NCT07661108
Phase
PHASE1
Status
Recruiting
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Conditions

  • Healthy

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • MK-8527 — DRUG
    Oral tablet
  • Probenecid — DRUG
    Oral tablet
  • Itraconazole — DRUG
    Oral solution

Study Details

Researchers are studying a medicine called MK-8527 to learn how it behaves in the body of healthy adults. The goal of this study is to learn about the effect of MK-8527 when it is taken with food or with other medicines. Researchers also want to learn about the safety of MK-8527 and if people tolerate it. Tolerate means participants will receive treatment in the trial unless they need to stop it due to health problems.

Key Dates

Start date
Jun 30, 2026
Status verified
Jun 2026
Primary completion
Oct 9, 2026
Completion
Oct 9, 2026

Study Design

Enrollment
44 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Part 1: MK-8527
    Participants will receive a single dose of MK-8527 with food and a single dose of MK-8527 without food.
  • Experimental: Part 2: MK-8527 + Probenecid
    Participants will receive a single dose of MK-8527 alone and a single dose of MK-8527 in combination with probenecid.
  • Experimental: Part 3: MK-8527 + Itraconazole
    Participants will receive a single dose of MK-8527 alone and a single dose of MK-8527 in combination with itraconazole.

Primary Outcome Measure

Part 1: Area Under the Concentration Time Curve From Time 0 to Infinity (AUC0-inf) of MK-8527 in Plasma With and Without Food [ Time Frame: Predose and at designated timepoints (up to 336 hours postdose) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Fortrea Clinical Research Unit Inc ( Site 0001)Daytona BeachFlorida32117
Study Coordinator
386-366-6400

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By research site
Fortrea Clinical Research Unit Inc· Daytona Beach, FL

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