DEPART Study at Yale

Conditions

• Dupuytren's Contracture

Eligibility Criteria

Sex

ALL

Age

30 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Radiation Therapy — RADIATION
  Radiation therapy (RT) should commence within 12 weeks of randomization in the prevention group and within 12 weeks of local treatment (NA) for the adjuvant group. RT will consist of 30Gy in 10 equal fractions. The RT schedule will be 5 initial fractions, then a 4-12 week break and then the final 5 fractions. Each group of 5 treatments must be delivered within a 7 day period.

Study Details

This is a randomized study to determine whether radiation therapy reduces the risk of progression / recurrence of Dupuytren's disease / contracture.

Key Dates

Start date

Aug 1, 2026

Status verified

Jun 2026

Primary completion

Jul 30, 2028

Completion

Dec 30, 2028

Study Design

Enrollment

158 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Radiation Therapy
  early stage DD (no flexion contraction in affected hand) - randomized to Radiotherapy
• No Intervention: Standard of Care
  Patients are receiving standard of care.

Primary Outcome Measure

Number of Participants with Passive Extension Deficit (PED) [ Time Frame: Day 0 (corresponding to the day of local treatment for intervention groups) and then at 6, 12, 24, 36, 48, 60, 84 and 108 months ]

Central Contacts

• Bruce McGibbon, MD
  203-8633-701
  [email protected]

Locations (1)

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