Construction of a Prospective Cohort Database for the Perioperative Period of Cardiac Surgery

Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study ID
NCT07662317
Status
Recruiting
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Conditions

  • Aortic Diseases
  • Coronary Artery Disease
  • Coronary Heart Disease
  • Valve Heart Disease

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cardiac surgey — PROCEDURE
    Cardiac surgey

Study Details

Cardiovascular disease (CVD) is the leading cause of global morbidity and mortality, with its prevalence increasing significantly from 1990 to 2019. Establishing a comprehensive cardiac surgery database is crucial for exploring perioperative prognostic factors and improving clinical outcomes. This muti-center, prospective observational study aims to construct a prospective cohort database for perioperative cardiac surgery. We plan to enroll adult patients who undergo cardiac surgery with cardiopulmonary bypass at the Second Affiliated Hospital of Zhejiang University and other hospitals from May 1, 2026 to December 31, 2031. Multi-dimensional perioperative data, including laboratory tests, hemodynamics, intraoperative echocardiography, and perioperative medications, will be collected and integrated, along with epidemiological data, clinical diagnosis and treatment information, multimodal data, and follow-up outcomes. An interconnected big data sharing platform will also be built. This database will provide a valuable resource for multi-level researches such as perioperative risk assessment, individualized prevention, precise diagnosis and treatment, and therapeutic efficacy monitoring. It will also help optimize surgical and perioperative management, improve the quality of cardiac surgery, and provide evidence for the refinement of China's healthcare system, ultimately enhancing perioperative safety and rehabilitation efficiency of patients.

Key Dates

First listed
Jun 23, 2026
Start date
Jun 25, 2026
Status verified
Apr 2026
Primary completion
May 31, 2031
Completion
May 31, 2032

Study Design

Enrollment
10,000 participants (estimated)

Arms

  • Arm: Perioperative Observation Group
    Patients undergoing cardiac surgery with cardiopulmonary bypass during the perioperative period (including, but not limited to, valve surgery, coronary artery bypass grafting, and combined procedures that require cardiopulmonary bypass)

Primary Outcome Measure

Incidence of major adverse cardiac and cerebrovascular events (MACCE) [ Time Frame: 4, 12 weeks and 1years after surgery ]

Central Contacts

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