Pilot Randomized Control Trial Comparing Oral Ketamine and Oral Oxycodone for Pain Control in Emergency Department Patients

Part of paid clinical trials in Albany, New York.

Sponsor
Albany Medical College
Study ID
NCT07670507
Phase
PHASE2/PHASE3
Status
Not Yet Recruiting

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Conditions

  • Pain Management

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • oral ketamine — DRUG
    A dose of oral ketamine administered as a second line pain management medicine in the emergency department.
  • oxycodone — DRUG
    A dose of oxycodone administered as a second line pain management medicine in the emergency department.

Study Details

The goal of this pilot randomized clinical trial is to learn if oral ketamine intervention can control pain in emergency department patients whose providers feel the need for additional pain medication. The main questions it aims to answer are: * Does oral ketamine result in a different mean change in pain scores compared with oral oxycodone? * Is there a difference in the need for additional opioid administration within 24 hours after the initial dose of study medication (oral ketamine vs oral oxycodone)? Researchers will compare oral ketamine to oral oxycodone to see if there is a difference in pain control or the need for additional opioid administration. Participants will: * Fill out a survey prior to study medication administration assessing pain scores, pain presentation, and medication history * Be randomized to and receive a dose of oral ketamine or oral oxycodone as the study medication for pain control * Fill out a survey assessing pain control, side effects, and safety outcomes * Receive follow-up phone calls at 1 and 3 months after enrollment to assess pain and opioid use

Key Dates

Start date
Jun 24, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: oral ketamine
    The oral ketamine arm will receive a dose of oral ketamine as a second line pain medication.
  • Active Comparator: oxycodone
    The oxycodone arm will receive a dose of oxycodone as a second line pain medication.

Primary Outcome Measure

Change in mean pain score [ Time Frame: This will be assessed at 30 minutes and 60 minutes after receiving the study drugs. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Albany Medical Center Emergency DepartmentAlbanyNew York12208
Michael Waxman, MD
[email protected]
518-262-3443
Andrew Chang, MD, MS
[email protected]
518-262-3443
Michael Waxman, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Albany Medical Center Emergency Department· Albany, NY

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