Acute Kidney Injury In Care Transitions (ACT): Pragmatic Clinical Trial

Part of paid clinical trials in Mankato, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT07670520
Status
Recruiting
Apply to this trial

Conditions

  • Acute Kidney Injury

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Acute Kidney Injury in Care Transitions (ACT) — BEHAVIORAL
    Clinicians will assign risk-individualized kidney health care prior to hospital discharge for acute kidney injury survivors. Low risk acute kidney injury survivors will receive education prior to hospital discharge, moderate risk acute kidney injury survivors will receive a referral to primary care for laboratory and clinical follow-up within approximately 14-days including a medication review by a pharmacist, and high risk acute kidney injury survivors will be referred to nephrologist-directed care including remote monitoring program (RPM) where available and aligned with the patients goals/values/preferences for up to 90 days after discharge for the highest risk patients.
  • Usual Care — BEHAVIORAL
    Physicians and nurse practitioners will provide standard of care education, labs, and clinical follow-up after discharge.

Study Details

The purpose of this study is to determine the effect of a multidisciplinary intervention at care transitions for acute kidney injury survivors on patient-centered outcomes.

Key Dates

Start date
Apr 16, 2026
Status verified
Jun 2026
Primary completion
Mar 31, 2030
Completion
Dec 31, 2030

Study Design

Enrollment
2,260 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Acute Kidney Injury in Care Transitions (ACT) Intervention
    Physicians and nurse practitioners randomized to the ACT intervention group will be provided access to augmented kidney care support for acute kidney injury patients prior to hospital discharge, individualized according to post-discharge risk.
  • Active Comparator: Usual Care
    Physicians and nurse practitioners randomized to the usual care group will provide standard of care education, labs, and clinical follow-up after discharge.

Primary Outcome Measure

Hospital-Free Days [ Time Frame: 90 days, 180 days, 1 year ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Mayo Clinic Health System-MankatoMankatoMinnesota56001
Mitchell C. Strand
507-293-0952
Jing Miao, M.D., Ph.D. (PRINCIPAL_INVESTIGATOR)
Mayo Clinic in RochesterRochesterMinnesota55905
Mitchell C. Strand
507-293-0952
Erin F. Barreto, Pharm.D., Ph.D. (PRINCIPAL_INVESTIGATOR)
Mayo Clinic Health System-Eau Claire ClinicEau ClaireWisconsin54703
Mitchell C. Strand
507-293-0952
Suhail B Shuja, M.D. (PRINCIPAL_INVESTIGATOR)

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Mayo Clinic Health System-Mankato· Mankato, MNMayo Clinic in Rochester· Rochester, MNMayo Clinic Health System-Eau Claire Clinic· Eau Claire, WI

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