Small RNA tRF-31 Changes in Patients With Age-Related Cataract

Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study ID
NCT07672899
Status
Recruiting
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Conditions

  • Cataract

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen collection (Anterior lens capsule) — PROCEDURE
    This is an observational study without investigational interventions. Participants will undergo standard-of-care phacoemulsification combined with intraocular lens implantation for age-related cataract. During the routine continuous curvilinear capsulorhexis (CCC) step of the surgery, the central anterior lens capsule, which is typically discarded as medical waste, will be collected for subsequent molecular analysis. This tissue collection relies entirely on the standard surgical procedure and does not alter the patient's routine clinical treatment pathway in any way.

Study Details

The goal of this observational study is to evaluate the expression characteristics and clinical relevance of the tRF-31/HIPK2 signaling axis in adults over 18 years old with age-related cataract (ARC). The main questions it aims to answer are: Is there a correlation between the relative expression levels of tRF-31 and its target gene HIPK2 in the anterior lens capsule and the clinical severity (Emery-Little grading system) of age-related cataracts? Does oxidative stress in the anterior segment microenvironment have a potential bystander effect on the state of the corneal endothelium? Participants will:Undergo routine preoperative ophthalmologic examinations, including visual acuity tests, slit-lamp photography, and corneal endothelial cell counting. Undergo standard cataract surgery (phacoemulsification combined with intraocular lens implantation) as part of their regular medical care. Allow researchers to collect and analyze their anterior lens capsule tissue, which is routinely removed and typically discarded as medical waste during the standard continuous curvilinear capsulorhexis (CCC) step of the surgery.

Key Dates

First listed
Jun 29, 2026
Start date
Jun 17, 2026
Status verified
Jun 2026
Primary completion
Aug 16, 2026
Completion
Sep 16, 2026

Study Design

Enrollment
200 participants (estimated)

Primary Outcome Measure

Correlation between relative expression of tRF-31 and cataract nuclear hardness (Emery-Little grading system) [ Time Frame: Baseline (Preoperative, up to 1 month prior to surgery) ]

Central Contacts

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