Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy

Part of paid clinical trials in Canfield, Ohio.

Sponsor
Nutraland USA, Inc.
Study ID
NCT07675200
Status
Recruiting
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Conditions

  • Autophagy
  • Healthy Aging

Eligibility Criteria

Sex
ALL
Age
40 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Spermidine — DIETARY_SUPPLEMENT
    Branded spermidine ingredient (Miricell® Rice Germ Extract) administered orally at a dose of 3.3 mg/day. Provided as a single opaque capsule to be ingested daily with water in the morning with a meal.
  • Placebo — DIETARY_SUPPLEMENT
    Placebo capsule (microcrystalline cellulose) packaged in an identical-looking, opaque capsule to be ingested daily with water in the morning with a meal.

Study Details

The goal of this clinical trial is to learn if a dietary supplement called Miricell works to improve cellular health and signs of healthy aging in adults. It will also learn about the safety of Miricell. The main questions it aims to answer are: * Does Miricell improve markers of autophagy, which is the body's natural process for recycling damaged cells? * Does Miricell support brain health, metabolic health, and visible signs of aging? * What medical problems, if any, do participants experience while taking Miricell? Researchers will compare Miricell to a placebo (a look-alike capsule that contains no active ingredients) to see if Miricell works better to support healthy aging. Participants will: * Take either one Miricell capsule or a placebo every day for 12 weeks with a morning meal. * Visit the research clinic four times over the course of the study for checkups and tests. * Complete memory and thinking tests, track their daily physical activity, and give blood samples to measure health changes.

Key Dates

Start date
Jan 9, 2026
Status verified
Jun 2026
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Miricell™
    Participants assigned to this arm will receive one capsule of the active branded spermidine supplement (Miricell) daily for a total duration of 12 weeks.
  • Placebo Comparator: Placebo
    Participants assigned to this arm will receive one look-alike placebo capsule daily for a total duration of 12 weeks.

Primary Outcome Measure

Serum Beclin-1 Concentration [ Time Frame: Baseline (Week 0), Week 6, and Week 12 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Center for Applied Health SciencesCanfieldOhio44406
Michael B La Monica, Ph.D., CSCS
[email protected]
330-206-0767

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By research site
The Center for Applied Health Sciences· Canfield, OH

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