Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?

Sponsor
Kanuni Sultan Suleyman Training and Research Hospital
Study ID
NCT07677072
Status
Recruiting
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Conditions

  • Fragility Fractures
  • Frailty
  • Osteoporosis
  • Postmenopausal Osteoporosis

Eligibility Criteria

Sex
FEMALE
Age
45 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Osteoporosis is a major cause of morbidity and fragility fractures in postmenopausal women. Bone mineral density (BMD) alone may not fully reflect fracture risk and skeletal fragility. Lumican, an extracellular matrix proteoglycan involved in collagen organization and musculoskeletal tissue homeostasis, has emerged as a potential biomarker for bone health. This prospective observational study aims to investigate the relationship between serum lumican levels, bone mineral density, muscle strength, and clinical fragility indicators in postmenopausal women. Approximately 100 participants will undergo routine osteoporosis assessment including DEXA, laboratory testing, FRAX evaluation, and handgrip strength measurement. The study will evaluate whether serum lumican levels can identify a hidden fragility phenotype beyond conventional bone mineral density measurements.

Key Dates

Start date
May 15, 2026
Status verified
Jun 2026
Primary completion
Dec 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
98 participants (estimated)

Arms

  • Arm: Postmenopausal Women Undergoing Osteoporosis Evaluation
    Postmenopausal women undergoing routine osteoporosis assessment will be included in this observational cohort. Participants will undergo bone mineral density measurement, routine osteoporosis laboratory evaluation, FRAX assessment, handgrip strength measurement, and serum lumican analysis. No treatment or interventional procedure will be administered as part of the study.

Primary Outcome Measure

Serum Lumican Level and Bone Mineral Density Association [ Time Frame: Baseline (at study enrollment) ]

Central Contacts

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