Targeting Fronto-Striatal Neural Circuitry Using Repetitive Transcranial Magnetic Stimulation to Reduce Irritability

Part of paid clinical trials in Hartford, Connecticut.

Sponsor
Yale University
Study ID
NCT07678060
Status
Active Not Recruiting

Conditions

  • Irritability
  • Mental Health

Eligibility Criteria

Sex
ALL
Age
18 Years - 25 Years
Healthy Volunteers
Not accepted

Interventions

  • repetitive transcranial magnetic stimulation (rTMS) — DEVICE
    Transcranial magnetic stimulation (TMS) is a noninvasive form of brain stimulation in which a changing magnetic field is used to cause electric current at a specific area of the brain through electromagnetic induction. To administer TMS, a stimulator equipped with a figure-8 coil will be used. Two separate coils will be used that are similar in appearance and acoustic properties. One active, unblinded, coil will be used to determine resting motor threshold (RMT) and deliver pulses for the recruitment curves; the other coil will be used to deliver rTMS. rTMS stimulation will be targeted to l-dlPFC.
  • fMRI — DIAGNOSTIC_TEST
    fMRI will be performed pre- and post rTMS

Study Details

This pilor study will use repetitive Transcranial Magnetic Stimulation (rTMS) as a noninvasive circuit-based neural modulation to test frontostriatal circuitry as a potential target to reduce irritability.

Key Dates

First listed
Jul 1, 2026
Start date
Sep 1, 2024
Status verified
Jun 2026
Primary completion
Aug 31, 2026
Completion
Aug 31, 2026

Study Design

Enrollment
20 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: rTMS participants
    Participants will be asked to complete a 3-day within-participant active and sham rTMS crossover study and perform tasks pre and post sessions while fMRI data is collected. Each will receive an active and sham rTMS.

Primary Outcome Measure

Frontostriatal connectivity [ Time Frame: Day 1-3 ]

Locations (1)

FacilityCityStateZIPSite coordinators
Hartford HealthcareHartfordConnecticut06102-

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By research site
Hartford Healthcare· Hartford, CT

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