Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training

Conditions

• Chronic Rhinosinusitis (CRS)
• Smell Loss

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Smell Training — OTHER
  Patients experiencing loss of smell from chronic rhinosinusitis (CRS)will undergo smell training.

Study Details

A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss. The impact of a 3-month olfactory training program on smell function, immunological changes, and mental health in patients with smell loss will be evaluated. The primary purpose of this study is to investigate tissue and blood samples to identify molecules that may be related to smell loss, ultimately aiming to develop future treatments for this condition and correlate with cognition.

Key Dates

Start date

Dec 9, 2025

Status verified

Jun 2026

Primary completion

Dec 31, 2026

Completion

Mar 31, 2027

Study Design

Enrollment

52 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Active Comparator: Group 1: - loss of smell + CRS with nasal polyps (CRSwNP)
  Loss of smell + CRS with nasal polyps (CRSwNP)
• Active Comparator: Group 2: - loss of smell with no CRS/no polyps - undergo 3 months of smell training
  Loss of smell + CRS with nasal polyps (CRSwNP) - undergo 3 months of smell training
• No Intervention: Control Group 1: - no loss of smell CRS with nasal polyps (CRSwNP)
  No loss of smell CRS with nasal polyps (CRSwNP)
• No Intervention: Control Group 2: -no loss of smell / no CRS/no polyps
  No loss of smell / no CRS/no polyps

Primary Outcome Measure

Primary Outcome Measure 1: Baseline olfactory function measured by UPSIT score [ Time Frame: Baseline ]

Central Contacts

• John O'Neill
  4405062611
  [email protected]
• Christopher Novicky
  216-444-7018
  [email protected]

Locations (1)

Find similar trials in Cleveland, OH

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