Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

Part of paid clinical trials in Walnut Creek, California.

Sponsor
Regeneron Pharmaceuticals
Study ID
NCT07685808
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Overweight or Obesity

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Olatorepatide — DRUG
    Administered per the protocol
  • Placebo — DRUG
    Administered per the protocol

Study Details

This study will test an experimental drug called olatorepatide ("study drug") to determine how safe and effective this drug is compared to placebo and how easily the body can accept this drug at different doses and dosing schedules without causing side effects, as well as how the drug is processed in the body by participants with overweight or obesity but do not have diabetes. The study is looking at: * What side effects the study drug might cause * How much study drug is in the blood at different times * How well the study drug works * What effects the study drug may have on the body at different dosing schedules * If the body makes antibodies to the study drug as this may cause the study drug to not work as well

Key Dates

First listed
Jul 6, 2026
Start date
Jul 28, 2026
Status verified
Aug 2026
Primary completion
Jan 21, 2028
Completion
Jan 21, 2028

Study Design

Enrollment
360 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Olatorepatide arm 1
  • Experimental: Olatorepatide arm 2
  • Experimental: Olatorepatide arm 3
  • Experimental: Olatorepatide arm 4
  • Experimental: Olatorepatide arm 5
  • Active Comparator: Matching Placebo arm 6

Primary Outcome Measure

Occurrence of Treatment-Emergent Adverse Events (TEAEs) [ Time Frame: Up to approximately 60 weeks ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
Diablo Clinical Research - Flourish ResearchWalnut CreekCalifornia94598-
K2 Medical Research Maitland LLC, Main OfficeMaitlandFlorida32751-
Charter Research LLC - The VillagesThe VillagesFlorida32162-
Clinical Site Partners, LLC DBA Flourish ResearchWinter ParkFlorida32789-
AMR Clinical - LexingtonLexingtonKentucky40509-

Find similar trials in Walnut Creek, CA

By research site
Diablo Clinical Research - Flourish Research· Walnut Creek, CAK2 Medical Research Maitland LLC, Main Office· Maitland, FLCharter Research LLC - The Villages· The Villages, FLClinical Site Partners, LLC DBA Flourish Research· Winter Park, FLAMR Clinical - Lexington· Lexington, KY

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