Verapamil Effect in Cystic Fibrosis-related Dysglycemia

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Rhode Island Hospital
Study ID
NCT07688070
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Abnormal Glucose Tolerance
  • Cystic Fibrosis (CF)
  • Cystic Fibrosis Related Diabetes

Eligibility Criteria

Sex
ALL
Age
14 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Verapamil Hydrochloride — DRUG
    Verapamil extended release (ER) will be initiated at a dose of 120mg daily and up-titrated over six weeks to target dose of 360mg daily as tolerated.

Study Details

We are conducting a pilot open-label pre/post interventional trial in adolescents and adults with cystic fibrosis (CF) and abnormal glucose tolerance or early CF-related diabetes mellitus (CFRD) to assess the safety and efficacy of verapamil on beta cell function and dysglycemia.

Key Dates

Start date
Jul 1, 2026
Status verified
May 2026
Primary completion
Jul 1, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Intervention Arm
    verapamil hydrochloride

Primary Outcome Measure

Change in 30-minute C-peptide area under the curve after mixed-meal tolerance test [ Time Frame: Baseline, 6 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Diabetes Research Center, Massachusetts General HospitalBostonMassachusetts02114
Melissa Putman
[email protected]
617-726-8722
Rhode Island HospitalProvidenceRhode Island02903
Kevin J Scully
[email protected]
401-444-5504

Find similar trials in Boston, MA

By research site
Diabetes Research Center, Massachusetts General Hospital· Boston, MARhode Island Hospital· Providence, RI

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